BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 beta' and Ligand = 'BDBM50166940'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GSK3beta (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112949 BindingDB Entry DOI: 10.7270/Q22V2KVV
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00931 BindingDB Entry DOI: 10.7270/Q2CF9V25
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of GSK-3beta (unknown origin)				Bioorg Med Chem Lett 28: 160-166 (2018) Article DOI: 10.1016/j.bmcl.2017.11.036 BindingDB Entry DOI: 10.7270/Q2NG4T7X
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01511 BindingDB Entry DOI: 10.7270/Q22Z19M2
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CSIC Curated by ChEMBL					Assay Description Inhibition of human recombinant GSK3beta expressed in Escherichia coli using GS-1 as substrate incubated for 20 mins by gamma[32P]ATP-based scintilla...				Eur J Med Chem 116: 281-289 (2016) Article DOI: 10.1016/j.ejmech.2016.03.035 BindingDB Entry DOI: 10.7270/Q2BP04P7
CSIC Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jamia Hamdard (Hamdard University) Curated by ChEMBL					Assay Description Inhibition of GSK3beta (unknown origin)				Eur J Med Chem 125: 464-477 (2017) Article DOI: 10.1016/j.ejmech.2016.09.058 BindingDB Entry DOI: 10.7270/Q2CN76CN
Jamia Hamdard (Hamdard University) Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant GSK3beta using GSK3 peptide as substrate preincubated for 15 mins followed by ATP addition and measured after 90 mins...				Citation and Details Article DOI: 10.1016/j.bmc.2021.115998 BindingDB Entry DOI: 10.7270/Q22F7S2S
TBA					More data for this Ligand-Target Pair