Found 5 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50149252' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149252
(3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse... |
J Med Chem 47: 3483-6 (2004)
Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149252
(3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor |
J Med Chem 48: 1169-78 (2005)
Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8 |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149252
(3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for Monkey gonadotropin-releasing hormone receptor |
J Med Chem 48: 1169-78 (2005)
Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8 |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50149252
(3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for Rat gonadotropin-releasing hormone receptor |
J Med Chem 48: 1169-78 (2005)
Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8 |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149252
(3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium flux |
J Med Chem 48: 1169-78 (2005)
Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8 |
More data for this Ligand-Target Pair | |