Found 2 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50149264' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149264
(3-((R)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-be...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)Cc2ccccc2)c1=O |wU:26.28,(11.77,3.73,;10.44,2.96,;10.44,1.42,;11.78,.65,;11.77,-.89,;10.44,-1.66,;9.11,-.87,;9.11,.65,;7.78,1.44,;7.77,-1.64,;7.77,-3.17,;9.1,-3.94,;6.42,-3.95,;6.42,-5.49,;7.75,-6.26,;7.75,-7.8,;6.42,-8.57,;9.08,-8.57,;10.43,-7.8,;10.43,-6.26,;9.08,-5.49,;10.18,-4.39,;5.09,-3.18,;3.76,-3.94,;5.09,-1.63,;3.76,-.86,;2.43,-1.62,;1.1,-.85,;2.43,-3.16,;1.1,-3.93,;-.23,-3.16,;-1.58,-3.92,;-1.58,-5.46,;-.23,-6.24,;1.1,-5.47,;6.44,-.86,;6.45,.68,)| Show InChI InChI=1S/C28H26F3N3O3/c1-17-25(20-10-6-13-24(37-2)26(20)31)27(35)34(15-19(32)14-18-8-4-3-5-9-18)28(36)33(17)16-21-22(29)11-7-12-23(21)30/h3-13,19H,14-16,32H2,1-2H3/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for human gonadotropin-releasing hormone receptor |
J Med Chem 48: 1169-78 (2005)
Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8 |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50149264
(3-((R)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-be...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)Cc2ccccc2)c1=O |wU:26.28,(11.77,3.73,;10.44,2.96,;10.44,1.42,;11.78,.65,;11.77,-.89,;10.44,-1.66,;9.11,-.87,;9.11,.65,;7.78,1.44,;7.77,-1.64,;7.77,-3.17,;9.1,-3.94,;6.42,-3.95,;6.42,-5.49,;7.75,-6.26,;7.75,-7.8,;6.42,-8.57,;9.08,-8.57,;10.43,-7.8,;10.43,-6.26,;9.08,-5.49,;10.18,-4.39,;5.09,-3.18,;3.76,-3.94,;5.09,-1.63,;3.76,-.86,;2.43,-1.62,;1.1,-.85,;2.43,-3.16,;1.1,-3.93,;-.23,-3.16,;-1.58,-3.92,;-1.58,-5.46,;-.23,-6.24,;1.1,-5.47,;6.44,-.86,;6.45,.68,)| Show InChI InChI=1S/C28H26F3N3O3/c1-17-25(20-10-6-13-24(37-2)26(20)31)27(35)34(15-19(32)14-18-8-4-3-5-9-18)28(36)33(17)16-21-22(29)11-7-12-23(21)30/h3-13,19H,14-16,32H2,1-2H3/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse... |
J Med Chem 47: 3483-6 (2004)
Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX |
More data for this Ligand-Target Pair | |