Found 3 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50272661' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50272661
![PNG](/data/jpeg/tenK5027/BindingDB_50272661.png) ((R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3...)Show SMILES Cc1c(-c2cccc(OCCCCCC(O)=O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F |r,wD:23.24,(33.36,-44.3,;32.03,-43.53,;32.03,-41.99,;33.36,-41.23,;34.69,-42.01,;36.02,-41.24,;36.03,-39.7,;34.69,-38.93,;34.69,-37.39,;36.02,-36.62,;36.02,-35.08,;37.35,-34.31,;37.35,-32.77,;38.68,-31.99,;38.68,-30.45,;40.02,-29.68,;37.35,-29.68,;33.36,-39.7,;32.02,-38.93,;30.7,-41.21,;30.7,-39.67,;29.37,-41.99,;28.03,-41.23,;26.7,-42,;26.71,-43.54,;25.37,-41.23,;25.37,-39.7,;24.03,-38.93,;22.7,-39.7,;22.71,-41.25,;24.05,-42.01,;29.37,-43.53,;28.04,-44.3,;30.7,-44.29,;30.7,-45.83,;29.91,-47.16,;30.75,-48.45,;32.28,-48.37,;30.05,-49.82,;28.5,-49.9,;27.67,-48.6,;28.37,-47.23,;27.54,-45.94,;26.72,-44.63,;26.24,-46.76,;28.84,-45.11,)| Show InChI InChI=1S/C33H32F5N3O5/c1-20-29(22-12-8-15-27(30(22)35)46-17-7-3-6-16-28(42)43)31(44)41(19-26(39)21-10-4-2-5-11-21)32(45)40(20)18-23-24(33(36,37)38)13-9-14-25(23)34/h2,4-5,8-15,26H,3,6-7,16-19,39H2,1H3,(H,42,43)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]tyr5,D-Leu6,NMeLeu7-GnRH from human cloned GnRH receptor expressed in RBL cells |
Bioorg Med Chem Lett 18: 4503-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.059 BindingDB Entry DOI: 10.7270/Q2QR4WZJ |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50272661
![PNG](/data/jpeg/tenK5027/BindingDB_50272661.png) ((R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3...)Show SMILES Cc1c(-c2cccc(OCCCCCC(O)=O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F |r,wD:23.24,(33.36,-44.3,;32.03,-43.53,;32.03,-41.99,;33.36,-41.23,;34.69,-42.01,;36.02,-41.24,;36.03,-39.7,;34.69,-38.93,;34.69,-37.39,;36.02,-36.62,;36.02,-35.08,;37.35,-34.31,;37.35,-32.77,;38.68,-31.99,;38.68,-30.45,;40.02,-29.68,;37.35,-29.68,;33.36,-39.7,;32.02,-38.93,;30.7,-41.21,;30.7,-39.67,;29.37,-41.99,;28.03,-41.23,;26.7,-42,;26.71,-43.54,;25.37,-41.23,;25.37,-39.7,;24.03,-38.93,;22.7,-39.7,;22.71,-41.25,;24.05,-42.01,;29.37,-43.53,;28.04,-44.3,;30.7,-44.29,;30.7,-45.83,;29.91,-47.16,;30.75,-48.45,;32.28,-48.37,;30.05,-49.82,;28.5,-49.9,;27.67,-48.6,;28.37,-47.23,;27.54,-45.94,;26.72,-44.63,;26.24,-46.76,;28.84,-45.11,)| Show InChI InChI=1S/C33H32F5N3O5/c1-20-29(22-12-8-15-27(30(22)35)46-17-7-3-6-16-28(42)43)31(44)41(19-26(39)21-10-4-2-5-11-21)32(45)40(20)18-23-24(33(36,37)38)13-9-14-25(23)34/h2,4-5,8-15,26H,3,6-7,16-19,39H2,1H3,(H,42,43)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]Pro-N-Et-GnRH from human cloned GnRH receptor expressed in HEK cells |
Bioorg Med Chem Lett 18: 4503-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.059 BindingDB Entry DOI: 10.7270/Q2QR4WZJ |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50272661
![PNG](/data/jpeg/tenK5027/BindingDB_50272661.png) ((R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3...)Show SMILES Cc1c(-c2cccc(OCCCCCC(O)=O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F |r,wD:23.24,(33.36,-44.3,;32.03,-43.53,;32.03,-41.99,;33.36,-41.23,;34.69,-42.01,;36.02,-41.24,;36.03,-39.7,;34.69,-38.93,;34.69,-37.39,;36.02,-36.62,;36.02,-35.08,;37.35,-34.31,;37.35,-32.77,;38.68,-31.99,;38.68,-30.45,;40.02,-29.68,;37.35,-29.68,;33.36,-39.7,;32.02,-38.93,;30.7,-41.21,;30.7,-39.67,;29.37,-41.99,;28.03,-41.23,;26.7,-42,;26.71,-43.54,;25.37,-41.23,;25.37,-39.7,;24.03,-38.93,;22.7,-39.7,;22.71,-41.25,;24.05,-42.01,;29.37,-43.53,;28.04,-44.3,;30.7,-44.29,;30.7,-45.83,;29.91,-47.16,;30.75,-48.45,;32.28,-48.37,;30.05,-49.82,;28.5,-49.9,;27.67,-48.6,;28.37,-47.23,;27.54,-45.94,;26.72,-44.63,;26.24,-46.76,;28.84,-45.11,)| Show InChI InChI=1S/C33H32F5N3O5/c1-20-29(22-12-8-15-27(30(22)35)46-17-7-3-6-16-28(42)43)31(44)41(19-26(39)21-10-4-2-5-11-21)32(45)40(20)18-23-24(33(36,37)38)13-9-14-25(23)34/h2,4-5,8-15,26H,3,6-7,16-19,39H2,1H3,(H,42,43)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human GnRH receptor expressed in RBL cells assessed as inhibition of GnRH-stimulated [3H]inositol phosphate hydrolysis by whol... |
Bioorg Med Chem Lett 18: 4503-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.059 BindingDB Entry DOI: 10.7270/Q2QR4WZJ |
More data for this Ligand-Target Pair | |