Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM430740'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430740 (US10550102, Example (+)-8. b)) Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C35H34F3N5O3/c1-20-18-24(21-14-16-42(17-15-21)33(44)23-8-9-23)11-12-27(20)40-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(41-28)43-32(35(36,37)38)26(19-39-43)34(45)46/h2-7,11-12,18-19,21,23,29,40H,8-10,13-17H2,1H3,(H,45,46)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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