Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM430859'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430859 (US10550102, Example 3b) Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C37H37F3N4O4/c1-3-47-36(46)28-21-41-44(34(28)37(38,39)40)32-9-5-8-29(42-32)27-7-4-6-24-12-15-31(33(24)27)48-30-14-13-26(20-22(30)2)23-16-18-43(19-17-23)35(45)25-10-11-25/h4-9,13-14,20-21,23,25,31H,3,10-12,15-19H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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