Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM430861'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430861 (US10550102, Example 4a) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12 Show InChI InChI=1S/C34H28F3N5O3/c35-34(36,37)32-27(33(43)44)18-39-42(32)30-9-4-8-28(40-30)26-7-3-5-21-11-13-29(31(21)26)45-25-12-10-23-19-41(16-14-22(23)17-25)20-24-6-1-2-15-38-24/h1-10,12,15,17-18,29H,11,13-14,16,19-20H2,(H,43,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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