Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM430863'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430863 (US10550102, Example 4b) Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12 Show InChI InChI=1S/C36H32F3N5O3/c1-2-46-35(45)29-20-41-44(34(29)36(37,38)39)32-11-6-10-30(42-32)28-9-5-7-23-13-15-31(33(23)28)47-27-14-12-25-21-43(18-16-24(25)19-27)22-26-8-3-4-17-40-26/h3-12,14,17,19-20,31H,2,13,15-16,18,21-22H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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