Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM430866'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430866 (US10550102, Example 10b) Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C38H43N5O3/c1-4-34-30(38(45)46-5-2)23-39-43(34)35-11-7-10-32(41-35)29-9-6-8-26-14-17-33(36(26)29)40-31-16-15-28(22-24(31)3)25-18-20-42(21-19-25)37(44)27-12-13-27/h6-11,15-16,22-23,25,27,33,40H,4-5,12-14,17-21H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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