Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1/beta-1' and Ligand = 'BDBM431005'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431005 (US10550102, Example 64-5) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC=C)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C37H40N4O5/c1-4-21-45-37(44)40-19-17-25(18-20-40)28-15-14-27(22-24(28)5-2)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-3)30(23-38-41)36(42)43/h4,7-12,14-15,22-23,25,33H,1,5-6,13,16-21H2,2-3H3,(H,42,43)/t33-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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