BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' and Ligand = 'BDBM281734'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281734 (US10023528, Example 10 \| US10259776, Example 10) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Institut de Biologie Structurale					Assay Description Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be...				J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q27083RX
Institut de Biologie Structurale					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM281734 (US10023528, Example 10 \| US10259776, Example 10) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	7.5	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to H�nicka et al, J. Mol. Med. 77, 14-23...				US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					More data for this Ligand-Target Pair