BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Heme oxygenase 1' and Ligand = 'BDBM50183062'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heme oxygenase 1 (Rattus norvegicus (rat))	BDBM50183062 (1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...) Show SMILES Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Catania Curated by ChEMBL					Assay Description Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...				Eur J Med Chem 148: 54-62 (2018) Article DOI: 10.1016/j.ejmech.2018.02.007 BindingDB Entry DOI: 10.7270/Q28P633V
University of Catania Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heme oxygenase 1 (Rattus norvegicus (rat))	BDBM50183062 (1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...) Show SMILES Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Catania Curated by ChEMBL					Assay Description Inhibition of recombinant truncated HO-1 (Met1 to Pro267) in rat spleen microsomes expressed in Escherichia coli by spectrometry based assay				Eur J Med Chem 167: 439-453 (2019) Article DOI: 10.1016/j.ejmech.2019.02.027 BindingDB Entry DOI: 10.7270/Q2P55S0Z
University of Catania Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heme oxygenase 1 (Rattus norvegicus (rat))	BDBM50183062 (1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...) Show SMILES Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queen's University Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat spleen HO1				J Med Chem 49: 4437-41 (2006) Article DOI: 10.1021/jm0511435 BindingDB Entry DOI: 10.7270/Q2GH9JR1
Queen's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heme oxygenase 1 (Rattus norvegicus (rat))	BDBM50183062 (1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...) Show SMILES Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queen's University Curated by ChEMBL					Assay Description Inhibition of HO1 in rat spleen microsomal fraction assessed as carbon monoxide production				J Med Chem 51: 5943-52 (2008) Article DOI: 10.1021/jm800505m BindingDB Entry DOI: 10.7270/Q2RX9BWZ
Queen's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heme oxygenase 1 (Rattus norvegicus (rat))	BDBM50183062 (1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)...) Show SMILES Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Queen's University Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat spleen microsome HO1				Bioorg Med Chem 15: 3225-34 (2007) Article DOI: 10.1016/j.bmc.2007.02.034 BindingDB Entry DOI: 10.7270/Q2MG7QBV
Queen's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)