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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127630'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9782415 (2017)


BindingDB Entry DOI: 10.7270/Q2P84F0G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US10758542 (2020)


BindingDB Entry DOI: 10.7270/Q2RB77PD
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...


US Patent US9796724 (2017)


BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US10758542, Example 3 | US...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


J Med Chem 50: 1876-85 (2007)


BindingDB Entry DOI: 10.7270/Q2R49T22
More data for this
Ligand-Target Pair