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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127646'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9782415 (2017)


BindingDB Entry DOI: 10.7270/Q2P84F0G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US10758542 (2020)


BindingDB Entry DOI: 10.7270/Q2RB77PD
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 74.2n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...


US Patent US9796724 (2017)


BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 74.3n/an/an/an/a7.5n/a



Array Biopharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8791123 (2014)


BindingDB Entry DOI: 10.7270/Q2Q23XX7
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US10758542, Example 19 | ...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r|
Show InChI InChI=1S/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


J Med Chem 50: 1876-85 (2007)


BindingDB Entry DOI: 10.7270/Q2R49T22
More data for this
Ligand-Target Pair