Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM344303'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344303 (US10251889, Example 12 | US10758542, Example 12 | ...) Show SMILES OC(=O)CC1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C24H25F2N5O3/c25-16-3-4-19(26)17(13-16)20-2-1-8-30(20)21-7-11-31-23(28-21)18(14-27-31)24(34)29-9-5-15(6-10-29)12-22(32)33/h3-4,7,11,13-15,20H,1-2,5-6,8-10,12H2,(H,32,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344303 (US10251889, Example 12 | US10758542, Example 12 | ...) Show SMILES OC(=O)CC1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C24H25F2N5O3/c25-16-3-4-19(26)17(13-16)20-2-1-8-30(20)21-7-11-31-23(28-21)18(14-27-31)24(34)29-9-5-15(6-10-29)12-22(32)33/h3-4,7,11,13-15,20H,1-2,5-6,8-10,12H2,(H,32,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344303 (US10251889, Example 12 | US10758542, Example 12 | ...) Show SMILES OC(=O)CC1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C24H25F2N5O3/c25-16-3-4-19(26)17(13-16)20-2-1-8-30(20)21-7-11-31-23(28-21)18(14-27-31)24(34)29-9-5-15(6-10-29)12-22(32)33/h3-4,7,11,13-15,20H,1-2,5-6,8-10,12H2,(H,32,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344303 (US10251889, Example 12 | US10758542, Example 12 | ...) Show SMILES OC(=O)CC1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C24H25F2N5O3/c25-16-3-4-19(26)17(13-16)20-2-1-8-30(20)21-7-11-31-23(28-21)18(14-27-31)24(34)29-9-5-15(6-10-29)12-22(32)33/h3-4,7,11,13-15,20H,1-2,5-6,8-10,12H2,(H,32,33)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair