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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT6A [507-778]' and Ligand = 'BDBM50527237'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527237
PNG
(CHEMBL4464974)
Show SMILES Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(c1)-c1ccccn1
Show InChI InChI=1S/C19H15F2N3O3S/c1-12-10-13(16-7-4-5-9-22-16)18(21)14(11-12)19(25)23-24-28(26,27)17-8-3-2-6-15(17)20/h2-11,24H,1H3,(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair