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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2' and Ligand = 'BDBM50287050'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2


(Homo sapiens (Human))		BDBM50287050
PNG
(CHEMBL4161265)
Show SMILES CCN(C1CCOCC1)c1cc2oc(Cl)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H30ClN3O5/c1-5-29(16-6-8-33-9-7-16)19-12-21-17(11-22(26)34-21)23(15(19)3)25(31)27-13-18-20(32-4)10-14(2)28-24(18)30/h10-12,16H,5-9,13H2,1-4H3,(H,27,31)(H,28,30)
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Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...

ACS Med Chem Lett 9: 98-102 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028
More data for this
Ligand-Target Pair