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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12' and Ligand = 'BDBM498157'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12


(Homo sapiens (Human))		BDBM498157
PNG
(US11013745, Compound SL-ZYE-147)
Show SMILES COC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12 |c:7|
Show InChI InChI=1S/C21H21FN6O3/c1-30-21(29)27-7-4-13(5-8-27)15-10-23-20(28-12-25-26-19(15)28)24-11-16-14-6-9-31-18(14)3-2-17(16)22/h2-4,10,12H,5-9,11H2,1H3,(H,23,24)
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US Patent
n/an/a 2.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...

US Patent US11013745 (2021)


BindingDB Entry DOI: 10.7270/Q2GX4FP4
More data for this
Ligand-Target Pair