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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12' and Ligand = 'BDBM498165'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12


(Homo sapiens (Human))		BDBM498165
PNG
(US11013745, Compound SL-ZYE-183)
Show SMILES COC(=O)N1CCC=C(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12 |c:7|
Show InChI InChI=1S/C22H23FN6O3/c1-31-22(30)28-8-2-3-14(6-9-28)16-11-24-21(29-13-26-27-20(16)29)25-12-17-15-7-10-32-19(15)5-4-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,25)
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US Patent
n/an/a 2.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...

US Patent US11013745 (2021)


BindingDB Entry DOI: 10.7270/Q2GX4FP4
More data for this
Ligand-Target Pair