Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM574837'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574837 (US11459315, Example 3 (isomer 2)) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N(C)C2(C)COC2)c2ccccc12 |r,wU:20.20,wD:18.19,(-5.1,-1.7,;-5.1,-.16,;-6.46,.64,;-7.7,-.09,;-9.17,.64,;-10.49,-.09,;-9.18,2.11,;-7.86,2.92,;-7.86,4.46,;-6.43,2.22,;-5.1,2.96,;-3.75,2.11,;-2.43,2.92,;-2.43,4.46,;-.99,2.22,;.36,2.81,;.73,4.35,;1.46,1.6,;3.01,1.82,;3.67,3.21,;3.96,.57,;5.5,.75,;6.38,-.46,;5.76,-1.85,;4.25,-2.04,;3.34,-.86,;6.71,-3.21,;6.09,-4.46,;8.29,-2.92,;8.29,-1.41,;9.28,-1.78,;10.49,-2.81,;9.54,-3.91,;.66,.35,;1.13,-1.16,;.14,-2.22,;-1.4,-1.93,;-1.84,-.46,;-.85,.61,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair