Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM574845'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574845 (US11459315, Example 7 (isomer 2)) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2OCC(CO2)N(C)C)c2ccccc12 |r,wU:20.26,wD:18.19,(-3.92,-1.65,;-3.92,-.11,;-5.25,.7,;-6.47,-.04,;-7.9,.7,;-9.19,-.04,;-7.91,2.21,;-6.62,2.98,;-6.62,4.52,;-5.22,2.25,;-3.93,3.02,;-2.6,2.21,;-1.28,3.02,;-1.28,4.56,;.12,2.28,;1.48,2.87,;1.78,4.46,;2.52,1.69,;3.99,1.91,;4.65,3.31,;4.95,.7,;6.46,.74,;7.22,-.5,;6.74,-1.91,;5.2,-1.99,;4.32,-.81,;7.66,-3.14,;7.06,-4.56,;9.19,-2.96,;1.71,.4,;2.18,-1.11,;1.23,-2.17,;-.28,-1.88,;-.73,-.37,;.23,.7,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair