Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM574915'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574915 (US11459315, Example 60 (isomer 2)) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)OC(F)F)c2ccccc12 |wU:18.19,wD:20.26,(-.53,5.89,;.97,6.21,;2.01,5.07,;3.51,5.39,;4.54,4.24,;6.05,4.56,;4.07,2.78,;2.56,2.46,;2.08,.99,;1.53,3.6,;.02,3.28,;-.45,1.82,;-1.96,1.5,;-2.99,2.64,;-2.44,.03,;-1.53,-1.21,;.01,-1.21,;-2.44,-2.46,;-1.96,-3.93,;-3.05,-5.01,;-.47,-4.32,;-.07,-5.81,;1.41,-6.21,;2.5,-5.12,;2.1,-3.63,;.62,-3.23,;3.99,-5.52,;5.08,-4.43,;4.68,-2.94,;6.57,-4.83,;-3.9,-1.98,;-5.23,-2.75,;-6.57,-1.98,;-6.57,-.44,;-5.23,.33,;-3.9,-.44,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair