Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM574921'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574921 (1-((R)-1-(1-(3-fluorocyclobutyl)piperidin-4-yl)eth...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC2)C2CC(F)C2)c2ccccc12 |wU:18.19,(-1.04,6.21,;.47,6.53,;1.5,5.39,;3,5.71,;4.03,4.56,;5.54,4.88,;3.56,3.1,;2.05,2.78,;1.58,1.31,;1.02,3.92,;-.48,3.6,;-.96,2.14,;-2.47,1.82,;-3.5,2.96,;-2.94,.35,;-2.04,-.89,;-.5,-.89,;-2.94,-2.14,;-2.47,-3.6,;-3.56,-4.69,;-.98,-4,;-.58,-5.49,;.91,-5.89,;2,-4.8,;1.6,-3.31,;.11,-2.91,;3.48,-5.2,;4.82,-4.43,;5.59,-5.76,;7.07,-6.16,;4.25,-6.53,;-4.41,-1.66,;-5.74,-2.43,;-7.07,-1.66,;-7.07,-.12,;-5.74,.65,;-4.41,-.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair