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Found 1 hit Enz. Inhib. hit(s) with Target = 'Homeobox protein Nkx-2.5/Transcription factor GATA-4' and Ligand = 'BDBM50249898'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Homeobox protein Nkx-2.5/Transcription factor GATA-4


(Mus musculus)		BDBM50249898
PNG
(CHEMBL1348312)
Show SMILES Cc1onc(c1C(=O)Nc1ccc(cc1)N1CCOCC1)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClN3O3/c1-14-19(20(24-28-14)17-4-2-3-5-18(17)22)21(26)23-15-6-8-16(9-7-15)25-10-12-27-13-11-25/h2-9H,10-13H2,1H3,(H,23,26)
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PC sid
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Similars
Article
PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a



Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...

J Med Chem 60: 7781-7798 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00816
BindingDB Entry DOI: 10.7270/Q2DN47GK
More data for this
Ligand-Target Pair