Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Homeobox protein Nkx-2.5/Transcription factor GATA-4' and Ligand = 'BDBM50249905'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homeobox protein Nkx-2.5/Transcription factor GATA-4 (Mus musculus)	BDBM50249905 (CHEMBL1571383) Show SMILES Cc1onc(c1C(=O)Nc1ccc(cc1)-c1nnc2CCCCCn12)-c1ccccc1 Show InChI InChI=1S/C24H23N5O2/c1-16-21(22(28-31-16)17-8-4-2-5-9-17)24(30)25-19-13-11-18(12-14-19)23-27-26-20-10-6-3-7-15-29(20)23/h2,4-5,8-9,11-14H,3,6-7,10,15H2,1H3,(H,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland. Curated by ChEMBL					Assay Description Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...				J Med Chem 60: 7781-7798 (2017) Article DOI: 10.1021/acs.jmedchem.7b00816 BindingDB Entry DOI: 10.7270/Q2DN47GK
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