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Found 1 hit Enz. Inhib. hit(s) with Target = 'Homeobox protein Nkx-2.5/Transcription factor GATA-4' and Ligand = 'BDBM50249950'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Homeobox protein Nkx-2.5/Transcription factor GATA-4


(Mus musculus)		BDBM50249950
PNG
(CHEMBL4078483)
Show SMILES CCOc1ccc(\C=C2/SC(=O)N(CC)C2=O)cc1
Show InChI InChI=1S/C14H15NO3S/c1-3-15-13(16)12(19-14(15)17)9-10-5-7-11(8-6-10)18-4-2/h5-9H,3-4H2,1-2H3/b12-9-
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...

J Med Chem 60: 7781-7798 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00816
BindingDB Entry DOI: 10.7270/Q2DN47GK
More data for this
Ligand-Target Pair