Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Homeobox protein Nkx-2.5/Transcription factor GATA-4' and Ligand = 'BDBM50249960'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homeobox protein Nkx-2.5/Transcription factor GATA-4 (Mus musculus)	BDBM50249960 (CHEMBL4068091) Show SMILES CC(C)CNC(=O)c1ccc(NC(=O)C2CC2)cc1 Show InChI InChI=1S/C15H20N2O2/c1-10(2)9-16-14(18)11-5-7-13(8-6-11)17-15(19)12-3-4-12/h5-8,10,12H,3-4,9H2,1-2H3,(H,16,18)(H,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland. Curated by ChEMBL					Assay Description Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...				J Med Chem 60: 7781-7798 (2017) Article DOI: 10.1021/acs.jmedchem.7b00816 BindingDB Entry DOI: 10.7270/Q2DN47GK
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