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Found 1 hit Enz. Inhib. hit(s) with Target = 'Homeobox protein Nkx-2.5/Transcription factor GATA-4' and Ligand = 'BDBM50249976'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Homeobox protein Nkx-2.5/Transcription factor GATA-4


(Mus musculus)		BDBM50249976
PNG
(CHEMBL4073403)
Show SMILES Cc1onc(c1C(=O)Nc1ccc(cc1)C(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-14-18(19(23-25-14)15-8-6-5-7-9-15)20(24)22-17-12-10-16(11-13-17)21(2,3)4/h5-13H,1-4H3,(H,22,24)
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...

J Med Chem 60: 7781-7798 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00816
BindingDB Entry DOI: 10.7270/Q2DN47GK
More data for this
Ligand-Target Pair