Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Hormone-sensitive lipase' and Ligand = 'BDBM120365'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hormone-sensitive lipase (Homo sapiens (Human))	BDBM120365 (US8703807, 1) Show SMILES O[C@@]1(CN2CCCC2=O)CC[C@]2(CCN(C2=O)c2ccc(cc2)C(F)(F)F)CC1 |r,wU:11.16,1.0,wD:1.1,(-4.32,1.91,;-3.92,.43,;-5.01,-.66,;-6.49,-.26,;-6.97,1.2,;-8.51,1.2,;-8.99,-.26,;-7.74,-1.17,;-7.74,-2.71,;-2.83,1.51,;-1.34,1.12,;-.94,-.37,;-.47,-1.84,;1.07,-1.84,;1.55,-.37,;.3,.53,;.3,2.07,;3.04,.03,;4.13,-1.06,;5.61,-.66,;6.01,.82,;4.92,1.91,;3.43,1.51,;7.5,1.22,;8.59,.13,;7.9,2.71,;8.99,1.62,;-2.03,-1.46,;-3.52,-1.06,)| Show InChI InChI=1S/C21H25F3N2O3/c22-21(23,24)15-3-5-16(6-4-15)26-13-11-19(18(26)28)7-9-20(29,10-8-19)14-25-12-1-2-17(25)27/h3-6,29H,1-2,7-14H2/t19-,20+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	7.2	4
Hoffmann-La Roche Inc. US Patent					Assay Description HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...				US Patent US8703807 (2014) BindingDB Entry DOI: 10.7270/Q2RN36HB
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