Found 2 hits Enz. Inhib. hit(s) with Target = 'IgG receptor FcRn large subunit p51' and Ligand = 'BDBM50270965' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
IgG receptor FcRn large subunit p51
(Homo sapiens (Human)) | BDBM50270965
((2R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{2-[(3R)-3-[(2S)-2...)Show SMILES CC(C)C[C@H](N(C)C(=O)CN1CCC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S)[C@@H](C)O)C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(O)=O |r,wU:102.107,83.86,18.26,62.65,14.14,98.104,wD:4.4,51.61,47.49,43.45,75.79,29.37,(27.77,-6.06,;27.77,-4.53,;29.1,-3.76,;26.45,-3.76,;26.45,-2.22,;25.24,-1.34,;25.35,.19,;23.88,-2.07,;23.83,-3.6,;22.58,-1.25,;21.22,-1.97,;21.17,-3.51,;19.81,-4.23,;18.51,-3.42,;18.56,-1.88,;17.26,-1.07,;15.9,-1.79,;15.91,-3.34,;14.62,-.93,;14.62,.63,;15.95,1.4,;17.28,.62,;18.61,1.39,;18.61,2.93,;17.27,3.7,;15.94,2.93,;13.39,-1.81,;12.04,-1.09,;12.04,.45,;10.76,-1.95,;10.76,-3.5,;12.1,-4.27,;13.56,-3.78,;14.47,-5.02,;13.58,-6.27,;12.11,-5.81,;9.37,-1.07,;8.01,-1.79,;8.02,-3.34,;6.74,-.93,;5.52,-1.81,;4.17,-1.09,;4.17,.45,;2.89,-1.95,;1.68,-1.07,;.34,-1.85,;.35,-3.39,;-1,-1.08,;-2.33,-1.87,;-3.69,-1.14,;-3.69,.41,;-4.98,-2.01,;-4.98,-3.56,;-3.64,-4.35,;-2.3,-3.57,;-.96,-4.35,;-.96,-5.89,;-2.3,-6.66,;-3.64,-5.89,;-6.19,-1.12,;-7.56,-1.84,;-7.55,-3.4,;-8.84,-.97,;-10.06,-1.87,;-8.84,.58,;-7.5,1.35,;-7.5,2.9,;-6.17,3.63,;-6.13,5.17,;-4.77,5.9,;-7.45,5.98,;-1.01,.47,;-2.56,.45,;-1.02,2.02,;.54,.47,;2.89,-3.5,;1.56,-4.27,;4.22,-4.27,;19.91,-1.15,;19.96,.39,;27.71,-1.37,;27.72,.17,;29.07,-2.09,;30.28,-1.21,;30.28,.33,;31.35,1.43,;32.84,1.04,;33.92,2.14,;33.51,3.62,;34.58,4.72,;32.01,4,;30.94,2.91,;31.54,-2.07,;31.55,-3.61,;32.9,-1.35,;33.12,.17,;34.63,.43,;35.35,-.92,;34.29,-2.03,;34.55,-3.55,;33.37,-4.53,;36,-4.08,;37.21,-3.21,;37.21,-1.65,;38.54,-.89,;38.48,-4.06,;39.84,-3.33,;38.49,-5.59,)| Show InChI InChI=1S/C72H102N18O16S2/c1-40(2)30-55(65(100)84-52(33-44-23-25-46(92)26-24-44)69(104)90-29-15-22-54(90)64(99)85-53(38-107)70(105)106)88(6)57(94)37-89-28-14-21-48(68(89)103)81-61(96)49(31-42-16-9-7-10-17-42)83-62(97)51(34-45-35-76-39-79-45)80-56(93)36-78-66(101)58(41(3)91)86-67(102)59(72(4,5)108)87-63(98)50(32-43-18-11-8-12-19-43)82-60(95)47(73)20-13-27-77-71(74)75/h7-12,16-19,23-26,35,39-41,47-55,58-59,91-92,107-108H,13-15,20-22,27-34,36-38,73H2,1-6H3,(H,76,79)(H,78,101)(H,80,93)(H,81,96)(H,82,95)(H,83,97)(H,84,100)(H,85,99)(H,86,102)(H,87,98)(H,105,106)(H4,74,75,77)/t41-,47+,48-,49+,50+,51+,52+,53+,54+,55+,58+,59+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntonix Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IgG binding to soluble human FcRn by ELISA |
Bioorg Med Chem 16: 6394-405 (2008)
Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C |
More data for this
Ligand-Target Pair | |
IgG receptor FcRn large subunit p51
(Homo sapiens (Human)) | BDBM50270965
((2R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{2-[(3R)-3-[(2S)-2...)Show SMILES CC(C)C[C@H](N(C)C(=O)CN1CCC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S)[C@@H](C)O)C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(O)=O |r,wU:102.107,83.86,18.26,62.65,14.14,98.104,wD:4.4,51.61,47.49,43.45,75.79,29.37,(27.77,-6.06,;27.77,-4.53,;29.1,-3.76,;26.45,-3.76,;26.45,-2.22,;25.24,-1.34,;25.35,.19,;23.88,-2.07,;23.83,-3.6,;22.58,-1.25,;21.22,-1.97,;21.17,-3.51,;19.81,-4.23,;18.51,-3.42,;18.56,-1.88,;17.26,-1.07,;15.9,-1.79,;15.91,-3.34,;14.62,-.93,;14.62,.63,;15.95,1.4,;17.28,.62,;18.61,1.39,;18.61,2.93,;17.27,3.7,;15.94,2.93,;13.39,-1.81,;12.04,-1.09,;12.04,.45,;10.76,-1.95,;10.76,-3.5,;12.1,-4.27,;13.56,-3.78,;14.47,-5.02,;13.58,-6.27,;12.11,-5.81,;9.37,-1.07,;8.01,-1.79,;8.02,-3.34,;6.74,-.93,;5.52,-1.81,;4.17,-1.09,;4.17,.45,;2.89,-1.95,;1.68,-1.07,;.34,-1.85,;.35,-3.39,;-1,-1.08,;-2.33,-1.87,;-3.69,-1.14,;-3.69,.41,;-4.98,-2.01,;-4.98,-3.56,;-3.64,-4.35,;-2.3,-3.57,;-.96,-4.35,;-.96,-5.89,;-2.3,-6.66,;-3.64,-5.89,;-6.19,-1.12,;-7.56,-1.84,;-7.55,-3.4,;-8.84,-.97,;-10.06,-1.87,;-8.84,.58,;-7.5,1.35,;-7.5,2.9,;-6.17,3.63,;-6.13,5.17,;-4.77,5.9,;-7.45,5.98,;-1.01,.47,;-2.56,.45,;-1.02,2.02,;.54,.47,;2.89,-3.5,;1.56,-4.27,;4.22,-4.27,;19.91,-1.15,;19.96,.39,;27.71,-1.37,;27.72,.17,;29.07,-2.09,;30.28,-1.21,;30.28,.33,;31.35,1.43,;32.84,1.04,;33.92,2.14,;33.51,3.62,;34.58,4.72,;32.01,4,;30.94,2.91,;31.54,-2.07,;31.55,-3.61,;32.9,-1.35,;33.12,.17,;34.63,.43,;35.35,-.92,;34.29,-2.03,;34.55,-3.55,;33.37,-4.53,;36,-4.08,;37.21,-3.21,;37.21,-1.65,;38.54,-.89,;38.48,-4.06,;39.84,-3.33,;38.49,-5.59,)| Show InChI InChI=1S/C72H102N18O16S2/c1-40(2)30-55(65(100)84-52(33-44-23-25-46(92)26-24-44)69(104)90-29-15-22-54(90)64(99)85-53(38-107)70(105)106)88(6)57(94)37-89-28-14-21-48(68(89)103)81-61(96)49(31-42-16-9-7-10-17-42)83-62(97)51(34-45-35-76-39-79-45)80-56(93)36-78-66(101)58(41(3)91)86-67(102)59(72(4,5)108)87-63(98)50(32-43-18-11-8-12-19-43)82-60(95)47(73)20-13-27-77-71(74)75/h7-12,16-19,23-26,35,39-41,47-55,58-59,91-92,107-108H,13-15,20-22,27-34,36-38,73H2,1-6H3,(H,76,79)(H,78,101)(H,80,93)(H,81,96)(H,82,95)(H,83,97)(H,84,100)(H,85,99)(H,86,102)(H,87,98)(H,105,106)(H4,74,75,77)/t41-,47+,48-,49+,50+,51+,52+,53+,54+,55+,58+,59+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 43 | n/a | n/a | n/a | 6.0 | n/a |
Syntonix Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human FcRn at pH 6 by surface plasmon resonance assay |
Bioorg Med Chem 16: 6394-405 (2008)
Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C |
More data for this
Ligand-Target Pair | |
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