BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50235921'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IDO1 in human SKOV3 cells				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127744 BindingDB Entry DOI: 10.7270/Q29S1VP1
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Inhibition of IDO1 in interferon-gamma-induced human SKOV3 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate measured af...				ACS Med Chem Lett 11: 179-187 (2020) Article DOI: 10.1021/acsmedchemlett.9b00572 BindingDB Entry DOI: 10.7270/Q2GX4FWT
Phenex Pharmaceuticals AG Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin E				Eur J Med Chem 126: 983-996 (2017) Article DOI: 10.1016/j.ejmech.2016.12.029 BindingDB Entry DOI: 10.7270/Q2RX9F9K
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in absence of GSH and pre...				Eur J Med Chem 126: 983-996 (2017) Article DOI: 10.1016/j.ejmech.2016.12.029 BindingDB Entry DOI: 10.7270/Q2RX9F9K
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human IDO1 assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 1.5 hrs by HPLC analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2016.05.061 BindingDB Entry DOI: 10.7270/Q2R49VGV
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human IDO1 in IFN-gamma-induced human MDA-MB-231 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate pretrea...				Citation and Details Article DOI: 10.1016/j.ejmech.2016.05.061 BindingDB Entry DOI: 10.7270/Q2R49VGV
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as ...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116160 BindingDB Entry DOI: 10.7270/Q2DF6W0V
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Guangxi Normal University Curated by ChEMBL					Assay Description Inhibition of recombinant human IDO1 using L-tryptophan as substrate incubated under dark conditions measured after 60 mins by fluorescence microplat...				J Med Chem 63: 1544-1563 (2020) Article DOI: 10.1021/acs.jmedchem.9b01386 BindingDB Entry DOI: 10.7270/Q2J969RJ
Guangxi Normal University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human IDO1 assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 1 hr by UV-vis spectroph...				Citation and Details Article DOI: 10.1016/j.ejmech.2016.05.061 BindingDB Entry DOI: 10.7270/Q2R49VGV
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as ...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116160 BindingDB Entry DOI: 10.7270/Q2DF6W0V
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-tagged IDO1 expressed in Escherichia coli Rosetta(DE3) pLysS using L-tryptophan as substrate measured after 1 hr b...				ACS Med Chem Lett 11: 179-187 (2020) Article DOI: 10.1021/acsmedchemlett.9b00572 BindingDB Entry DOI: 10.7270/Q2GX4FWT
Phenex Pharmaceuticals AG Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of IDO1 (unknown origin) by enzymatic assay				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127744 BindingDB Entry DOI: 10.7270/Q29S1VP1
TBA					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysis				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50235921 (CHEMBL584991) Show SMILES Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N\O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysis				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair