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Found 1 hit Enz. Inhib. hit(s) with Target = 'Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM449736'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]


(Homo sapiens (Human))		BDBM449736
PNG
(US10703733, Example 349 | US10988451, Example 349 ...)
Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3|
Show InChI InChI=1S/C40H52ClN5O6S/c1-27-5-3-7-36(50-2)33-11-8-30(33)21-46-25-40(14-4-6-28-19-31(41)10-12-34(28)40)26-52-37-13-9-29(20-35(37)46)38(47)42-53(49,24-27)43-39(48)45-22-32(23-45)44-15-17-51-18-16-44/h3,7,9-10,12-13,19-20,27,30,32-33,36H,4-6,8,11,14-18,21-26H2,1-2H3,(H,42,43,47,48,49)/b7-3+/t27-,30-,33+,36-,40-,53-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0260n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...

US Patent US10988451 (2021)


BindingDB Entry DOI: 10.7270/Q2M048KN
More data for this
Ligand-Target Pair