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Found 1 hit Enz. Inhib. hit(s) with Target = 'Inosine-5'-monophosphate dehydrogenase' and Ligand = 'BDBM50467866'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Inosine-5'-monophosphate dehydrogenase


(Cryptococcus neoformans var. neoformans serotype D...)		BDBM50467866
PNG
(CHEMBL4289187)
Show SMILES CC(=O)Nc1ccc(cc1)-c1nnc(SC2=CS(=O)(=O)c3ccccc23)o1 |t:16|
Show InChI InChI=1S/C18H13N3O4S2/c1-11(22)19-13-8-6-12(7-9-13)17-20-21-18(25-17)26-15-10-27(23,24)16-5-3-2-4-14(15)16/h2-10H,1H3,(H,19,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD

Bioorg Med Chem 26: 5408-5419 (2018)


Article DOI: 10.1016/j.bmc.2018.09.004
BindingDB Entry DOI: 10.7270/Q2KK9FGT
More data for this
Ligand-Target Pair