Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50349713' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50349713
(CHEMBL1809056)Show SMILES COc1cc(CC(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12 Show InChI InChI=1S/C24H23ClN6O3/c1-33-20-12-16(13-22(32)30-8-10-34-11-9-30)5-6-18(20)28-24-27-14-17(25)23(29-24)19-15-26-21-4-2-3-7-31(19)21/h2-7,12,14-15H,8-11,13H2,1H3,(H,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of auto-phosphorylation of IGFR1 |
Bioorg Med Chem Lett 21: 4702-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50349713
(CHEMBL1809056)Show SMILES COc1cc(CC(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12 Show InChI InChI=1S/C24H23ClN6O3/c1-33-20-12-16(13-22(32)30-8-10-34-11-9-30)5-6-18(20)28-24-27-14-17(25)23(29-24)19-15-26-21-4-2-3-7-31(19)21/h2-7,12,14-15H,8-11,13H2,1H3,(H,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay |
Bioorg Med Chem Lett 21: 4702-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q |
More data for this Ligand-Target Pair | |