Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50349720' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50349720
(CHEMBL1809063)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C26H29ClN8O2/c1-32(2)24(36)17-33-10-12-34(13-11-33)18-7-8-20(22(14-18)37-3)30-26-29-15-19(27)25(31-26)21-16-28-23-6-4-5-9-35(21)23/h4-9,14-16H,10-13,17H2,1-3H3,(H,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of auto-phosphorylation of IGFR1 |
Bioorg Med Chem Lett 21: 4702-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50349720
(CHEMBL1809063)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C26H29ClN8O2/c1-32(2)24(36)17-33-10-12-34(13-11-33)18-7-8-20(22(14-18)37-3)30-26-29-15-19(27)25(31-26)21-16-28-23-6-4-5-9-35(21)23/h4-9,14-16H,10-13,17H2,1-3H3,(H,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay |
Bioorg Med Chem Lett 21: 4702-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q |
More data for this Ligand-Target Pair | |