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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50437363'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50437363
PNG
(CHEMBL3037919)
Show SMILES CN1CCN(CC1)[C@H]1C[C@H](C1)c1nc(-c2ccc3c(Oc4ccccc4)cc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:9.12,7.7,(67.57,-36.98,;66.66,-35.74,;65.13,-35.9,;64.22,-34.66,;64.85,-33.25,;66.38,-33.07,;67.29,-34.33,;63.94,-32.01,;62.42,-31.78,;62.65,-30.26,;64.18,-30.49,;61.74,-29.01,;62.21,-27.55,;60.96,-26.65,;60.95,-25.1,;59.6,-24.34,;59.6,-22.79,;60.93,-22.02,;60.94,-20.48,;59.6,-19.71,;59.6,-18.16,;60.94,-17.4,;60.94,-15.86,;59.6,-15.09,;58.27,-15.86,;58.27,-17.4,;62.27,-19.71,;63.6,-20.47,;63.61,-22.02,;62.27,-22.79,;62.27,-24.33,;64.93,-19.7,;66.27,-20.47,;67.6,-19.69,;67.59,-18.15,;66.25,-17.38,;64.92,-18.16,;59.72,-27.56,;58.23,-27.24,;57.75,-25.78,;57.2,-28.38,;57.67,-29.84,;59.18,-30.17,;60.2,-29.02,)|
Show InChI InChI=1S/C36H35N7O/c1-41-16-18-42(19-17-41)27-20-26(21-27)36-40-33(34-35(37)38-14-15-43(34)36)25-12-13-29-31(22-25)39-30(24-8-4-2-5-9-24)23-32(29)44-28-10-6-3-7-11-28/h2-15,22-23,26-27H,16-21H2,1H3,(H2,37,38)/t26-,27+
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MMDB

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n/an/a 195n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...

ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair