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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50437371'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50437371
PNG
(CHEMBL3037911)
Show SMILES C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3c(Oc4ccccc4)cc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:1.1,4.6,wD:1.0,(41.6,-16.89,;40.11,-16.49,;40.51,-17.98,;40.35,-14.97,;38.83,-14.74,;38.6,-16.26,;37.92,-13.5,;38.39,-12.03,;37.14,-11.13,;37.13,-9.59,;35.78,-8.82,;35.78,-7.28,;37.11,-6.51,;37.11,-4.96,;35.78,-4.19,;35.78,-2.65,;37.12,-1.88,;37.12,-.35,;35.79,.44,;34.45,-.36,;34.46,-1.88,;38.44,-4.19,;39.78,-4.95,;39.79,-6.5,;38.45,-7.28,;38.45,-8.81,;41.11,-4.18,;42.45,-4.95,;43.78,-4.17,;43.77,-2.63,;42.42,-1.87,;41.1,-2.64,;35.9,-12.04,;34.41,-11.73,;33.93,-10.26,;33.38,-12.87,;33.85,-14.33,;35.36,-14.65,;36.38,-13.51,)|
Show InChI InChI=1S/C32H27N5O2/c1-32(38)18-22(19-32)31-36-28(29-30(33)34-14-15-37(29)31)21-12-13-24-26(16-21)35-25(20-8-4-2-5-9-20)17-27(24)39-23-10-6-3-7-11-23/h2-17,22,38H,18-19H2,1H3,(H2,33,34)/t22-,32+
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n/an/a 23n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...

ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair