Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM188843'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188843 (US9169260, 109) Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cc(Br)cnc12)C1CCN(CC1)C1CCCOC1 Show InChI InChI=1S/C27H30BrN7O2/c1-18-4-6-21(7-5-18)35-25(31-27(36)23-15-30-34-16-20(28)14-29-26(23)34)13-24(32-35)19-8-10-33(11-9-19)22-3-2-12-37-17-22/h4-7,13-16,19,22H,2-3,8-12,17H2,1H3,(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
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