Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-2 (Homo sapiens (Human)) | BDBM387266 (N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01403 BindingDB Entry DOI: 10.7270/Q2C82F4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-2 (Homo sapiens (Human)) | BDBM387266 (N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells... | Bioorg Med Chem Lett 18: 1958-62 (2008) BindingDB Entry DOI: 10.7270/Q2D50Q8B | |||||||||||
More data for this Ligand-Target Pair |