BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Intestinal-type alkaline phosphatase' and Ligand = 'BDBM18073'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Intestinal-type alkaline phosphatase (Homo sapiens (Human))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Inhibition of IAP by analogous luminescence assay				Bioorg Med Chem 18: 573-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.012 BindingDB Entry DOI: 10.7270/Q24T6JHR
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Intestinal-type alkaline phosphatase (Bos taurus (Cattle))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	9.8	37
COMSATS Institute of Information Technology					Assay Description Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...				Bioorg Chem 70: 229-236 (2017) Article DOI: 10.1016/j.bioorg.2017.01.003 BindingDB Entry DOI: 10.7270/Q2K07334
COMSATS Institute of Information Technology					More data for this Ligand-Target Pair
Intestinal-type alkaline phosphatase (Homo sapiens (Human))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Rostock Curated by ChEMBL					Assay Description Inhibition of human IAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by ...				Eur J Med Chem 144: 116-127 (2018) Article DOI: 10.1016/j.ejmech.2017.11.068 BindingDB Entry DOI: 10.7270/Q2W66PDP
Universit£t Rostock Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Intestinal-type alkaline phosphatase (Bos taurus (Cattle))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	9.8	37
Quaid-I-Azam University					Assay Description The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...				Chem Biol Drug Des 89: 365-370 (2017) Article DOI: 10.1111/cbdd.12861 BindingDB Entry DOI: 10.7270/Q2F47N10
Quaid-I-Azam University					More data for this Ligand-Target Pair
Intestinal-type alkaline phosphatase (Bos taurus (Cattle))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Forman Christian College (A Chartered University) Curated by ChEMBL					Assay Description Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric...				Bioorg Med Chem 23: 2435-44 (2015) Article DOI: 10.1016/j.bmc.2015.03.054 BindingDB Entry DOI: 10.7270/Q2WW7KC8
					More data for this Ligand-Target Pair
Intestinal-type alkaline phosphatase (Bos taurus (Cattle))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Rostock Curated by ChEMBL					Assay Description Inhibition of calf intestinal alkaline phosphatase using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured a...				Eur J Med Chem 126: 408-420 (2017) Article DOI: 10.1016/j.ejmech.2016.11.036 BindingDB Entry DOI: 10.7270/Q2DZ0BKR
Universit£t Rostock Curated by ChEMBL					More data for this Ligand-Target Pair
Intestinal-type alkaline phosphatase (Homo sapiens (Human))	BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid \| CHEMBL301523...) Show SMILES N[C@@H](Cc1ccccc1)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by sub...				Eur J Med Chem 159: 282-291 (2018) Article DOI: 10.1016/j.ejmech.2018.09.063 BindingDB Entry DOI: 10.7270/Q23N263P
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)