Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) (Homo sapiens (Human)) | BDBM135818 (US10085990, Example 92 | US10568888, Example 92 | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4... | US Patent US9833457 (2017) BindingDB Entry DOI: 10.7270/Q26W9DB9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) (Homo sapiens (Human)) | BDBM135818 (US10085990, Example 92 | US10568888, Example 92 | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | 30 |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe... | US Patent US9393245 (2016) BindingDB Entry DOI: 10.7270/Q2JH3K2T | |||||||||||
More data for this Ligand-Target Pair |