Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] ' and Ligand = 'BDBM585803'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human))	BDBM585803 (US11530229, Compound 18) Show SMILES C[C@H]1C[C@@H](C)CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)C1 |r,wU:37.43,wD:28.30,1.0,3.3,(-10.75,-2.39,;-9.21,-2.39,;-8.44,-3.72,;-6.9,-3.72,;-6.5,-5.21,;-6.13,-2.39,;-6.9,-1.06,;-6.13,.28,;-4.59,.28,;-3.82,1.61,;-2.28,1.61,;-1.25,2.76,;-1.57,4.26,;.16,2.13,;-0,.6,;-1.51,.28,;-2.28,-1.06,;-3.82,-1.06,;-1.51,-2.39,;-2.28,-3.72,;.03,-2.39,;-.74,-3.72,;1.49,2.9,;1.49,4.44,;2.82,5.21,;4.16,4.44,;4.16,2.9,;2.82,2.13,;5.49,2.13,;4.16,1.36,;4.16,-.18,;2.91,-1.09,;3.39,-2.55,;4.93,-2.55,;5.4,-1.09,;6.87,-.61,;6.58,1.04,;7.67,2.13,;6.58,3.22,;9.21,2.13,;10.75,2.13,;-8.44,-1.06,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2280CGT
					More data for this Ligand-Target Pair