Found 3 hits Enz. Inhib. hit(s) with Target = 'Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] ' and Ligand = 'BDBM585806' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585806
(US11530229, Compound 21)Show SMILES Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(c1)N1Cc2c(cc(CN[C@@H]3CCC(F)(F)C3)cc2C(F)(F)F)C1=O |r,wU:9.12,27.29,wD:7.14,(7.67,-1.35,;6.2,-1.83,;5.73,-3.29,;4.19,-3.29,;3.71,-1.83,;4.96,-.92,;4.96,.62,;6.29,1.39,;7.38,.3,;8.47,1.39,;7.38,2.48,;10.01,1.39,;11.55,1.39,;4.96,2.16,;4.96,3.7,;3.62,4.47,;2.29,3.7,;2.29,2.16,;3.62,1.39,;.96,1.39,;.8,-.15,;-.71,-.47,;-1.48,.87,;-3.02,.87,;-3.79,-.47,;-5.33,-.47,;-6.1,-1.8,;-7.64,-1.8,;-8.55,-.55,;-10.01,-1.03,;-10.01,-2.57,;-11.55,-2.57,;-10.01,-4.11,;-8.55,-3.04,;-3.02,-1.8,;-1.48,-1.8,;-.71,-3.13,;-1.48,-4.47,;.83,-3.13,;.06,-4.47,;-.45,2.01,;-.77,3.52,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this
Ligand-Target Pair | |
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585806
(US11530229, Compound 21)Show SMILES Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(c1)N1Cc2c(cc(CN[C@@H]3CCC(F)(F)C3)cc2C(F)(F)F)C1=O |r,wU:9.12,27.29,wD:7.14,(7.67,-1.35,;6.2,-1.83,;5.73,-3.29,;4.19,-3.29,;3.71,-1.83,;4.96,-.92,;4.96,.62,;6.29,1.39,;7.38,.3,;8.47,1.39,;7.38,2.48,;10.01,1.39,;11.55,1.39,;4.96,2.16,;4.96,3.7,;3.62,4.47,;2.29,3.7,;2.29,2.16,;3.62,1.39,;.96,1.39,;.8,-.15,;-.71,-.47,;-1.48,.87,;-3.02,.87,;-3.79,-.47,;-5.33,-.47,;-6.1,-1.8,;-7.64,-1.8,;-8.55,-.55,;-10.01,-1.03,;-10.01,-2.57,;-11.55,-2.57,;-10.01,-4.11,;-8.55,-3.04,;-3.02,-1.8,;-1.48,-1.8,;-.71,-3.13,;-1.48,-4.47,;.83,-3.13,;.06,-4.47,;-.45,2.01,;-.77,3.52,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this
Ligand-Target Pair | |
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585806
(US11530229, Compound 21)Show SMILES Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(c1)N1Cc2c(cc(CN[C@@H]3CCC(F)(F)C3)cc2C(F)(F)F)C1=O |r,wU:9.12,27.29,wD:7.14,(7.67,-1.35,;6.2,-1.83,;5.73,-3.29,;4.19,-3.29,;3.71,-1.83,;4.96,-.92,;4.96,.62,;6.29,1.39,;7.38,.3,;8.47,1.39,;7.38,2.48,;10.01,1.39,;11.55,1.39,;4.96,2.16,;4.96,3.7,;3.62,4.47,;2.29,3.7,;2.29,2.16,;3.62,1.39,;.96,1.39,;.8,-.15,;-.71,-.47,;-1.48,.87,;-3.02,.87,;-3.79,-.47,;-5.33,-.47,;-6.1,-1.8,;-7.64,-1.8,;-8.55,-.55,;-10.01,-1.03,;-10.01,-2.57,;-11.55,-2.57,;-10.01,-4.11,;-8.55,-3.04,;-3.02,-1.8,;-1.48,-1.8,;-.71,-3.13,;-1.48,-4.47,;.83,-3.13,;.06,-4.47,;-.45,2.01,;-.77,3.52,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this
Ligand-Target Pair | |
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