Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] ' and Ligand = 'BDBM585838'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human))	BDBM585838 (US11530229, Compound 53) Show SMILES Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(NC(=O)c2cc(CN3CCC4(CC4)C3)cc(n2)C2CC2)c1 |r,wU:9.12,wD:7.14,(8.11,-3.9,;8.58,-2.44,;10.05,-1.96,;10.05,-.42,;8.58,.05,;7.68,-1.19,;6.14,-1.19,;5.37,.14,;6.46,1.23,;5.37,2.32,;4.28,1.23,;5.37,3.86,;5.37,5.4,;4.6,-1.19,;5.37,-2.53,;4.6,-3.86,;3.06,-3.86,;2.29,-2.53,;.75,-2.53,;-.02,-1.19,;.75,.14,;-1.56,-1.19,;-2.33,.14,;-3.87,.14,;-4.61,1.47,;-6.15,1.47,;-7.05,.23,;-8.52,.7,;-8.52,2.24,;-9.14,3.65,;-10.05,2.4,;-7.05,2.72,;-4.64,-1.19,;-3.87,-2.53,;-2.33,-2.53,;-4.64,-3.86,;-5.98,-4.63,;-4.64,-5.4,;3.06,-1.19,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl...				Citation and Details BindingDB Entry DOI: 10.7270/Q2280CGT
					More data for this Ligand-Target Pair