Found 3 hits Enz. Inhib. hit(s) with Target = 'Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] ' and Ligand = 'BDBM585841' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585841
(US11530229, Compound 56)Show SMILES C[C@@H]1CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)C2CC2)CCO1 |r,wU:29.34,wD:20.21,1.0,(-9.64,4.14,;-8.87,2.81,;-7.33,2.81,;-6.56,1.47,;-5.02,1.47,;-4.28,.14,;-5.05,-1.19,;-4.28,-2.53,;-2.74,-2.53,;-1.97,-1.19,;-2.74,.14,;-.43,-1.19,;.34,.14,;.34,-2.53,;1.88,-2.53,;2.65,-3.86,;4.19,-3.86,;4.96,-2.53,;4.19,-1.19,;2.65,-1.19,;4.96,.14,;5.73,-1.19,;7.27,-1.19,;8.17,.05,;9.64,-.42,;9.64,-1.96,;8.17,-2.44,;7.7,-3.9,;6.05,1.23,;4.96,2.32,;3.87,1.23,;4.96,3.86,;4.96,5.4,;-5.05,-3.86,;-6.39,-4.63,;-5.05,-5.4,;-7.33,.14,;-8.87,.14,;-9.64,1.47,)| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this Ligand-Target Pair | |
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585841
(US11530229, Compound 56)Show SMILES C[C@@H]1CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)C2CC2)CCO1 |r,wU:29.34,wD:20.21,1.0,(-9.64,4.14,;-8.87,2.81,;-7.33,2.81,;-6.56,1.47,;-5.02,1.47,;-4.28,.14,;-5.05,-1.19,;-4.28,-2.53,;-2.74,-2.53,;-1.97,-1.19,;-2.74,.14,;-.43,-1.19,;.34,.14,;.34,-2.53,;1.88,-2.53,;2.65,-3.86,;4.19,-3.86,;4.96,-2.53,;4.19,-1.19,;2.65,-1.19,;4.96,.14,;5.73,-1.19,;7.27,-1.19,;8.17,.05,;9.64,-.42,;9.64,-1.96,;8.17,-2.44,;7.7,-3.9,;6.05,1.23,;4.96,2.32,;3.87,1.23,;4.96,3.86,;4.96,5.4,;-5.05,-3.86,;-6.39,-4.63,;-5.05,-5.4,;-7.33,.14,;-8.87,.14,;-9.64,1.47,)| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this Ligand-Target Pair | |
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
(Homo sapiens (Human)) | BDBM585841
(US11530229, Compound 56)Show SMILES C[C@@H]1CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)C2CC2)CCO1 |r,wU:29.34,wD:20.21,1.0,(-9.64,4.14,;-8.87,2.81,;-7.33,2.81,;-6.56,1.47,;-5.02,1.47,;-4.28,.14,;-5.05,-1.19,;-4.28,-2.53,;-2.74,-2.53,;-1.97,-1.19,;-2.74,.14,;-.43,-1.19,;.34,.14,;.34,-2.53,;1.88,-2.53,;2.65,-3.86,;4.19,-3.86,;4.96,-2.53,;4.19,-1.19,;2.65,-1.19,;4.96,.14,;5.73,-1.19,;7.27,-1.19,;8.17,.05,;9.64,-.42,;9.64,-1.96,;8.17,-2.44,;7.7,-3.9,;6.05,1.23,;4.96,2.32,;3.87,1.23,;4.96,3.86,;4.96,5.4,;-5.05,-3.86,;-6.39,-4.63,;-5.05,-5.4,;-7.33,.14,;-8.87,.14,;-9.64,1.47,)| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The ability of candidate compounds to displace a known inhibitor and thereby inhibit Cbl-b activity was measured by monitoring the interaction of Cbl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280CGT |
More data for this Ligand-Target Pair | |