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Found 1 hit Enz. Inhib. hit(s) with Target = 'Lanosterol synthase' and Ligand = 'BDBM50456341'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lanosterol synthase


(Homo sapiens (Human))		BDBM50456341
PNG
(CHEMBL4212932)
Show SMILES Cl.CN(C)CCOc1ccc(OC2CCN(CC2)S(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H27FN2O4S/c1-23(2)15-16-27-18-5-7-19(8-6-18)28-20-11-13-24(14-12-20)29(25,26)21-9-3-17(22)4-10-21/h3-10,20H,11-16H2,1-2H3
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n/an/a 120n/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology (AIST)

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR method

J Med Chem 61: 5047-5053 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00484
BindingDB Entry DOI: 10.7270/Q2NK3HN7
More data for this
Ligand-Target Pair