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Found 1 hit Enz. Inhib. hit(s) with Target = 'Legumain' and Ligand = 'BDBM50499748'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Legumain


(Homo sapiens (Human))		BDBM50499748
PNG
(CHEMBL3742218)
Show SMILES NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1Cl)C#N |r|
Show InChI InChI=1S/C15H16Cl2N4O4S/c16-9-3-4-13(11(17)6-9)26(24,25)21-5-1-2-12(21)15(23)20-10(8-18)7-14(19)22/h3-4,6,10,12H,1-2,5,7H2,(H2,19,22)(H,20,23)/t10-,12-/m0/s1
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PC cid
PC sid
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Article
PubMed
n/an/a 593n/an/an/an/an/an/a



Queen's University Belfast

Curated by ChEMBL


Assay Description
Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysis

Bioorg Med Chem Lett 25: 5642-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.001
BindingDB Entry DOI: 10.7270/Q2280BM6
More data for this
Ligand-Target Pair