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Found 1 hit Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527]' and Ligand = 'BDBM239252'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527]


(Homo sapiens (Human))
BDBM239252
PNG
(US9416126, D68)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC(C)C)cc12
Show InChI InChI=1S/C20H25FN6O3S/c1-4-31(28,29)27-7-5-26(6-8-27)19-11-17(22-12-23-19)20-14-9-18(30-13(2)3)15(21)10-16(14)24-25-20/h9-13H,4-8H2,1-3H3,(H,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.24n/an/an/an/a8.525



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well...


US Patent US9416126 (2016)


BindingDB Entry DOI: 10.7270/Q2D50KV9
More data for this
Ligand-Target Pair