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Found 1 hit Enz. Inhib. hit(s) with Target = 'Lipopolysaccharide-induced tumor necrosis factor-alpha factor' and Ligand = 'BDBM235378'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lipopolysaccharide-induced tumor necrosis factor-alpha factor


(Homo sapiens (Human))		BDBM235378
PNG
(US10085990, Example 110 | US9393245, 110)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(c2)C#N)c1=O
Show InChI InChI=1S/C24H20N4O3/c1-31-20-11-5-10-18-21(20)26-14-19-22(18)27(16-7-2-3-8-16)24(30)28(23(19)29)17-9-4-6-15(12-17)13-25/h4-6,9-12,14,16H,2-3,7-8H2,1H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 123n/an/an/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
Samples were tested for TNF as per the manufacturer's instructions (TNF ELISA; R&D Systems, Cat #DY210). The samples were serially diluted with P...

US Patent US10085990 (2018)


BindingDB Entry DOI: 10.7270/Q2RV0QRM
More data for this
Ligand-Target Pair