BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM456472'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456472
PNG
(US10723742, Example 198 | US11510915, Example 198)
Show SMILES CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@](C)(N)C1
Show InChI InChI=1S/C31H29F3N4O2/c1-30(2,40)16-37-10-8-19-12-24(26(33)27(34)28(19)37)22-7-6-20(29(39)38-11-9-31(3,36)17-38)13-23(22)18-4-5-21(15-35)25(32)14-18/h4-8,10,12-14,40H,9,11,16-17,36H2,1-3H3/t31-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a


TBA

Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC6513
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456472
PNG
(US10723742, Example 198 | US11510915, Example 198)
Show SMILES CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@](C)(N)C1
Show InChI InChI=1S/C31H29F3N4O2/c1-30(2,40)16-37-10-8-19-12-24(26(33)27(34)28(19)37)22-7-6-20(29(39)38-11-9-31(3,36)17-38)13-23(22)18-4-5-21(15-35)25(32)14-18/h4-8,10,12-14,40H,9,11,16-17,36H2,1-3H3/t31-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


US Patent US10723742 (2020)


BindingDB Entry DOI: 10.7270/Q2TF01DB
More data for this
Ligand-Target Pair